Polycystic Kidney Disease in Selkirk Rexs
Polycystic kidney disease can occur in Selkirk Rexs, though it is most prevalent in Persian-related breeds. Cysts develop in the kidneys and gradually enlarge, potentially leading to kidney failure. DNA testing and ultrasound screening are available for early detection.
Prevalence
Less common in non-Persian breeds
Typical Onset
Cysts present from birth; kidney failure typically 7-10 years
Severity
Severe
Symptoms to Watch For
If your Selkirk Rex shows any of these signs, monitor closely and consult your veterinarian.
Risk Factors
- •possible outcross heritage from Persian lines
- •autosomal dominant inheritance — one copy sufficient
- •unscreened breeding stock
- •lack of DNA testing before purchase
Diagnosis
Ultrasound reveals multiple cysts in both kidneys — can be detected as early as 10 weeks of age in affected cats. DNA testing for the PKD1 gene mutation is definitive in Persians and related breeds. Blood work shows progressive elevation of kidney values as cysts enlarge and destroy functional tissue.
Treatment
No cure — management mirrors chronic kidney disease. Renal diet, hydration support, phosphate binders, anti-nausea medication. Cyst drainage is not practical (they refill). Early detection allows proactive management before kidney failure develops. Prognosis depends on cyst burden — some cats live full lifespans with mild disease; severe cases progress to renal failure by age 7-8.
Prevention
DNA testing of all breeding cats — PKD1 mutation has autosomal dominant inheritance (only one copy needed to cause disease). No cat positive for PKD1 should be bred. Screening has dramatically reduced prevalence in responsible breeding programs.
When to See a Vet
See your vet for DNA testing if you have a Persian, Exotic, or related breed. Annual kidney values monitoring for positive cats. See vet urgently if you notice increased drinking/urination or appetite loss.
Other Health Conditions in Selkirk Rexs
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